Basic Science Research


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Prostate cancer and Plexin B1 gene

This research group has studied the genetic changes that allow prostate cancer cells to metastasise, and has discovered that mutations are frequent in a gene called Plexin B1 that controls cell migration. About 50% of primary prostate cancers and nearly all bone metastases carry one or more mutations in Plexin B1. The goal now is to target the Plexin B1 signalling pathway in order to slow down or prevent metastasis and target cells carrying mutated Plexin B1.

Chief Investigator - Prof John Masters, UCL

Wed, 21st Aug, 2019